While estrogens play a leading role in womens skin, other hormones such as progesterone, the androgens, androstenedione, and testosterone also have an influence on dermal health and well-being with aging, which have been reviewed in detail elsewhere [10]
Concurrently, ammonium metabolites exhibit mitochondrial toxicity, collapsing membrane potential, and depleting ATP, while nutrient stress activates AMPK to phosphorylate ULK1, initiating pro-survival autophagy (201, 202)
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